个人简介：

李岩松，男，医学博士，副研究员，陕西中医药大学硕士研究生指导教师。现任西安交通大学第一附属医院麻醉手术部副主任，住院医生规范化培训麻醉专业基地教学主任；中国民族卫生协会卫生健康技术推广专家委员会常务委员，中国心胸血管麻醉学会非心脏手术麻醉分会委员，中国医药教育协会麻醉专业委员会委员。

学习工作经历：

2025/01至今 西安交通大学麻醉手术部，副主任

2024/10至今 西安交通大学麻醉手术部，住院医生规范化培训麻醉科专业基地教学主任

2024/01至今 西安交通大学麻醉手术部，副研究员

2017/07-2023/12 西安交通大学麻醉手术部，助理研究员

2014/09-2017/07，四川大学，麻醉系，博士研究生，导师：左云霞教授

2011/09-2014/07，四川大学，麻醉系，硕士研究生，导师：魏新川教授

2006/09-2011/07，山西医科大学，麻醉系，学士

研究方向：

主要从事术后快速康复的临床、基础与转化研究，围绕喉罩应用及气管导管定位发表系列文章，开发气管导管深度定位新方法，发表SCI论文7篇；围绕糖尿病认知功能障碍及其线粒体功能紊乱开展系列研究：1. 证实小胶质细胞内源性果糖代谢通过上调NOX4促进ROS生成损伤神经元突触，诱发DACD，丰富了糖尿病中枢代谢异常理论；2. 阐明星形胶质细胞NDRG2参与运动锻炼改善DACD的整合分子机制，从微观角度证实星形胶质细胞NDRG2作为一种潜在的保护因素，抑制NF-κB/C3/C3aR信号逆转神经元突触损伤，改善DACD；3.证实上调海马神经元小凹蛋白-1可抑制线粒体分裂、促进线粒体自噬，改善铁死亡，缓解DACD，为防治DACD提供了新靶点；进而全面透彻地总结了小凹蛋白在线粒体功能调控以及认知障碍相关疾病中的重要作用，揭示了其在治疗认知障碍方面的潜力。目前以（共同）第一和（共同）通讯作者在Exp Mol Med（IF：12.8）、 Ebiomedicine（IF: 11.1）、Cell Commun Signal （IF: 8.4）、Resuscitation（IF: 6.251）、Ultraschall Med（IF: 6.548）、Mol Med（IF：5.7）等杂志发表SCI论文21篇，主持国家自然科学基金项目2项、陕西省自然科学基金青年项目1项、西安交通大学基本科研业务费1项、吴阶平基金会项目1项，获批国家发明专利1项。

科研课题：

1. 国家自然科学基金面上项目，柠檬酸合酶β-羟基丁酰化修饰下降诱发神经元β-羟基丁酸代谢障碍介导DACD的机制研究，82471216，2025/1-2028/12，在研，48万元，主持。

2. 吴阶平基金会急性疼痛优化管理专项研究课题，奥赛利定用于腹腔镜胃癌根治术后患者自控镇痛的有效性及安全性的单中心、随机、双盲对照试验，2025/1-2027/12，10万，在研，主持。

3. 西安交通大学基本科研业务费，KHK依赖的海马小胶质细胞内源性果糖代谢双重调控NOX4介导DACD的机制研究，xzy012023130，2023/1-2025/12，在研，10万元，主持。

4. 陕西省自然基金青年基金，Cav-1调控GPX4抑制铁死亡改善糖尿病认知功能障碍的机制研究，2022JQ-819，2022/1-2023/12，已结题，5万元，主持。

5. 国家自然科学基金青年基金，血小板触发内皮细胞管腔面PECAM-1“扩散性诱陷”介导肺毛细血管漏的机制研究，81801899，2019/1-2021/12，已结题，21万元，主持。

发表论文：

1. Juan Hu^#, Qiao Li^#, Shiqiu Jiang, Yingying Deng, Lan Yang, Mengyu Du, Shuxuan He, Fuxing Xu, Chaoying Yan, Wei Gao,Yansong Li^*, Yaomin Zhu^*. Peripheral Mitochondrial Transplantation Alleviates Diabetes-Associated Cognitive Dysfunction by Suppressing Cuproptosis. Brain Res Bull. 2025 Feb 7:222:111245. (IF=3.5)

2. Haiqing Chang^#, Haifeng Zhang^#, Shiqiu Jiang, Juan Hu, Hongli Ma, Bo Cheng,Qiang Wang^*,Yansong Li^*.Targeting enteric glial CRF-R1/Cx43 attenuates stress-induced accelerated colonic motility. (IF=3.0)

3. Fuxing Xu^#, Juan Hu^#, Xuying Li, Lan Yang, Shiqiu Jiang, Tao Jiang, Bo Cheng, Hailiang Du, Ruiduo Wang, Yingying Deng, Wei Gao,Yansong Li^*, Yaomin Zhu^*. Inhibition of platelet activation alleviates blood-brain barrier injury and diabetes-associated cognitive dysfunction. Brain Res Bull. 2025 Jan 17:221:111211. (IF=3.5)

4. Wenxin Tang^#, Chaoying Yan^#, Shuxuan He, Mengyu Du, Bo Cheng, Bin Deng, Shan Zhu,Yansong Li^*, Qiang Wang^*. Neuron-targeted overexpression of caveolin-1 alleviates diabetes-associated cognitive dysfunction via regulating mitochondrial fission-mitophagy axis. Cell Commun Signal. 2023 Dec 15;21(1):357.(IF=8.4)

5. Yansong Li^#, Tao Jiang^#, Mengyu Du#, Shuxuan He, Ning Huang, Bo Cheng, Chaoying Yan, Wenxin Tang, Wei Gao, Hongyan Guo, Qiao Li, Qiang Wang. Ketohexokinase-dependent metabolism of cerebral endogenous fructose in microglia drives diabetes-associated cognitive dysfunction. Exp Mol Med. 2023 Nov; 55(11): 2417-2432. (IF=12.8)

6. Tao Jiang^#,Yansong Li^#, Shuxuan He, Ning Huang, Mengyu Du, Qian Zhai, Kairui Pu, Meiyan Wu, Chaoying Yan, Zhi Ma, Qiang Wang. Reprogramming astrocytic NDRG2/NF-κB/C3 signaling restores the diabetes-associated cognitive dysfunction. EBioMedicine. 2023 Jul;93:104653. (IF=11.205)

7. Tingting Yang, Chaoying Yan, Lan Yang, Jialu Tan, Shiqiu Jiang, Juan Hu, Wei Gao, Qiang Wang^*,Yansong Li^*. Identification and validation of core genes for type 2 diabetes mellitus by integrated analysis of single-cell and bulk RNA-sequencing. Eur J Med Res. 2023 Sep 12;28(1):340.( IF=4.2)

8. Yansong Li^#, Mengyu Du^#, Shuxuan He, Ruiduo Wang*, Zaikun Zhang, Qiang Wang*. Sensitive label-free hemoglobin detection based on polydopamine functionalized graphene oxide coated micro-tapered long-period fiber grating. Optik. 275 (2023) 170626. (IF=2.84)

9. Mengyu Du^#, Tao Jiang^#, Shuxuan He, Bo Cheng, Xin Zhang, Liya Li, Lan Yang, Wei Gao,Yansong Li^*, Qiang Wang*. Sigma-1 Receptor as a Protective Factor for Diabetes-Associated Cognitive Dysfunction via Regulating Astrocytic Endoplasmic Reticulum-Mitochondrion Contact and Endoplasmic Reticulum Stress. Cells. 2023 Jan 3;12(1):197. (IF=7.666)

10. Bo Cheng^#, Mengyu Du^#, Shuxuan He, Lan Yang, Xi Wang, Hui Gao, Haiqing Chang, Wei Gao, Yan Li, Qiang Wang,Yansong Li. Inhibition of platelet activation suppresses reactive enteric glia and mitigates intestinal barrier dysfunction during sepsis. Mol Med. 2022 Nov 18;28(1):137. (IF=6.376)

11. Wenxin Tang^#,Yansong Li^#, Shuxuan He, Tao Jiang, Nan Wang, Mengyu Du, Bo Cheng, Wei Gao, Yan Li*, Qiang Wang*. Caveolin-1 Alleviates Diabetes-Associated Cognitive Dysfunction Through Modulating Neuronal Ferroptosis-Mediated Mitochondrial Homeostasis. Antioxid Redox Signal. 2022 May 27. (IF=8.401)

12. Wenxin Tang^#,Yansong Li^#, Yan Li*, Qiang Wang*. Caveolin-1, a Novel Player in Cognitive Decline. Neurosci Biobehav Rev. 2021 Oct;129:95-106. (IF:8.989)

13. Yansong Li^#, Yubo Wang^#, Haiqing Chang, Bo Cheng, Jiwen Miao, Shuang Li, Hao Hu, Liyu Huang, Qiang Wang. Inhibitory Effects of Dexmedetomidine and Propofol on Gastrointestinal Tract Motility Involving Impaired Enteric Glia Ca²⁺ Response in Mice. Neurochem Res. 2021 Jun;46(6): 1410-22. (IF:3.996)

14. Hongli Ma, Tao Jiang, Wenxin Tang, Zhi Ma, Kairui Pu, Fuxing Xu, Haiqing Chang, Ge Zhao, Wei Gao,Yansong Li^*, Qiang Wang^*. Transplantation of platelet-derived mitochondria alleviates cognitive impairment and mitochondrial dysfunction in db/db mice. Clin Sci (Lond). 2020 Aug;134(16):2161-75. (IF:6.124)

15. 安睿, 申新, 李爽, 王强,李岩松*.血小板与肠道屏障功能的研究进展. 中华危重症医学杂志（电子版）, 2020, 13(2):145-8．(IF: 0.940)

16. 李爽, 程波, 王强,李岩松*.血小板与内皮细胞屏障功能.中华危重症医学杂志（电子版）, 2019, 12(1):56-60．(IF: 0.940)

17. Jing Wang, Hui Gong,Yansong Li*. Was capnographic waveform the gold standard to confirm the endotracheal intubation? We need more proofs. Resuscitation, 2017 Oct, 119 :e11. (IF:5.262)

18. Yansong Li^#, Ying Xie^#, Bailong Hu^#, Jing Wang^#, Haibo Song^*, Xinchuan Wei^*. Sensitivity and Specificity of a Novel Approach to Confirm the Depth of the Endotracheal Tube: A Pilot Study. Medicine (Baltimore). 2015 Aug;94(34):e1460. (IF:1.889)

19. Yansong Li, Jing Wang, Xinchuan Wei*. Confirmation of endotracheal tube depth using ultrasound in adults. Can J Anaesth. 2015 Jul;62(7):832. (IF:3.779)

20. Yansong Li, Jing Wang, Xinchuan Wei*. Confirmation of the depth of the endotracheal tube: Where should the cuff be? Resuscitation.2015 Mar,88: e7-e7 (IF: 5.262)

21. Yansong Li, Ying Xie, Xinchuan Wei*. Confirmation of the depth of the endotracheal tube by ultrasound. Ultraschall Med. 2014 Dec;35(6):575. (IF:6.548)

22. Yansong Li, Jing Wang, Xinchuan Wei*. Ultrasound for identifying tracheal tube position during cardiopulmonary resuscitation. Resuscitation. 2014 Jan;85(1):e5. (IF: 5.262)

23. Yansong Li, Ying Xie, Xinchuan Wei*. A novel method for SLIPA™ size selection, for adult patients, on the basis of chamber length. J Anesth. 2013 Aug;27(4):557-62. (IF:2.078)

24. 李岩松,魏新川*,陈向东.后腹腔镜手术中呼气末二氧化碳分压急剧升高一例.临床麻醉学杂志, 2013 , 29 (4) :364. (IF: 1.201)

授权专利：

(1) 朱耀民，李岩松. 一种可视可调双腔支气管导管及其制造方法：中国，ZL202411239410.1，国家发明专利；

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