个人简介：

殷峻，男，1973年出生，医学博士，主任医师，教授，陕西中医药大学硕士研究生指导教师、上海交通大学医学院博士研究生导师。现任上海交通大学附属第六人民医院内分泌代谢科主任医师、上海市第六人民医院金山分院副院长。兼任中华医学会内科学分会委员、中国中西医结合学会内分泌专委会委员、中国生物物理学会肥胖症研究分会副秘书长、上海市中西医结合学会内分泌专委会副主任委员、上海市食疗研究会糖尿病专委会副主任委员等职务。

学习工作经历：

1998年七年制硕士毕业于上海中医药大学，2001年博士毕业于上海第二医科大学。先后在上海第二医科大学附属新华医院、美国Pennington生物医学研究中心、美国弗吉利亚联邦大学、上海交通大学医学院附属第六人民医院工作，主要从事内分泌代谢病临床与科研工作20余年。

研究方向：

糖尿病与肥胖的治疗及机制研究

科研课题：

（1）国家重点研发计划（2023YFF0713705），多模成像引导脉冲电场消融系统关键技术研发与产业化及推广应用，2023-2026，在研，负责人。

（2）国家自然科学基金面上项目（82070885），Mt-nd1调控线粒体复合物I功能在糖脂代谢中的作用及机制研究，2021-2024，已结题，负责人。

（3）国家自然科学基金面上项目（81670790），电子传递链复合物I抑制剂调控脂代谢的机制，2017-2020，已结题，负责人。

（4）国家自然科学基金面上项目（31171128），线粒体电子传递链复合物I——调节糖脂代谢的新靶点，2012年1月-2015年12月，已结题，负责人。

（5）上海市浦江人才计划（11PJ1407700），复合物I功能抑制改善糖代谢的机制研究，2011-2013，已结题，负责人。

发表论文：

(1) Cai L, Xia X, Gu Y, Hu L, Li C, Ma X*,Yin J*. Opposite effects of low-carbohydrate high-fat diet on metabolism in humans and mice.Lipids Health Dis. 2023 Nov 10;22(1):191.

(2) Xia X, Xu M, Gu Y, Li Y, Li L*,Yin J*. Low-carbohydrate diet in the treatment of type 2 diabetes mellitus (LoCaT): study protocol for a multicenter, randomized controlled trial.Trials. 2023 Jun 19;24(1):411.

(3) Wang W, Wan J, Du W, Song J, Lu Y, Gu S, Feng Y, Wang G, Tao M*,Yin J*. Delayed treatment with nirmatrelvir/ritonavir could remain effective in patients with Omicron BA2.2 variant of COVID-19.Ann Acad Med Singap 2023 Mar;52(3):158-60.

(4) Wu Y, Feng Y, Wan J, Du W, Tao M, Gu S,Yin J*. Cycle threshold values are not associated with mortality: Risk factor analysis in older patients with the SARS-CoV-2 Omicron variant.Travel Med Infect Dis. 2023 Feb 20, 52:102555 .

(5) Hu L, Xia X, Zong Y, Gu Y, Wei L,Yin J*. Calorie Restriction Enhanced Glycogen Metabolism to Compensate for Lipid Insufficiency.Mol Nutr Food Res. 2022 Oct;66(20):e2200182.

(6) Gao F, Li C, Wang Y, Lu J, Lu W, Zhou J,Yin J*, Ma X*. Growth differentiation factor 15 is not associated with glycemic control in patients with type 2 diabetes mellitus treated with metformin: a post-hoc analysis of AIM study.BMC Endocr Disord. 2022 Oct 22;22(1):256.

(7) Song J, Xia X, Lu Y, Wan J, Chen H,Yin J*. Relationship among Insulin Therapy, Insulin Resistance, and Severe Coronary Artery Disease in Type 2 Diabetes Mellitus.J Interv Cardiol. 2022 Sep 26;2022:2450024.

(8) Hu L, Ma L, Xia X, Ying T, Zhou M, Zou S, Yu H,Yin J*. Efficacy of bariatric surgery in the treatment of women with obesity and polycystic ovary syndrome.J Clin Endocrinol Metab. 2022 Jul 14;107(8):e3217-e3229.

(9) Lingwen Ying#, Yong Zhang#,Jun Yin#, Yufei Wang, Wei Lu, Wei Zhu, Yuqian Bao, Jian Zhou. Classic Type 1 Diabetes Mellitus and Fulminant Type 1 Diabetes Mellitus: Similarity and Discrepancy of Immunological Characteristics and Cytokine Profile.Diabetes Metab Syndr Obes. 2021 Nov 30;14:4661-4670.

(10) Ye Lu, Lili Hu, Jing Song, Jing Wan, Haibing Chen*,Jun Yin*. Gallstone disease and nonalcoholic fatty liver disease in patients with type 2 diabetes: a cross-sectional study.BMC Endocr Disord, 2021 Nov 19;21(1):231 .

(11) Cai L,Yin J^#, Ma X, Mo Y, Li C, Lu W, Bao Y, Zhou J, Jia W. Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized clinical trial.Front Med, 2021 Jun;15(3):460-471.

(12) Muyu Yu, Miriayi Alimujiang, Lili Hu, Fang Liu, Yuqian Bao,Jun Yin*. Berberine alleviates lipid metabolism disorders via inhibition of mitochondrial complex I in gut and liver.Int J Biol Sci, 2021 Apr 12; 17(7): 1693-1707.

(13) Ying L, Zhang M, Ma X, Si Y, Li X, Su J,Yin J*, Bao Y*. Macrophage LAMTOR1 Deficiency Prevents Dietary Obesity and Insulin Resistance Through Inflammation-Induced Energy Expenditure.Front Cell Dev Biol. 2021 May 20;9:672032.

(14) Lingli Cai, Cheng Li, Yufei Wang, Yifei Mo,Jun Yin*, Xiaojing Ma*. Increased Serum GDF15 Related to Improvement in Metabolism by Lifestyle Intervention Among Young Overweight and Obese Adults.Diabetes Metab Syndr Obes, 2021 Mar 17;14:1195-1202 .

(15) Linlin Ji, Qianqian Wang, Mengdan Liu, Chaoyu Zhu, Yuanyuan Xiao, Junfeng Han, Yunyun Fang, Jianping Ye,Jun Yin*, Li Wei*. The 14-3-3 protein YWHAB inhibits glucagon-induced hepatic gluconeogenesis through interacting with the glucagon receptor and FOXO1.FEBS Lett.2021 May;595(9):1275-1288.

(16) Zhao WJ, Xia XY,Yin J*. Relationship of serum vitamin D levels with diabetic microvascular complications in patients with type 2 diabetes mellitus.Chinese Medical Journal, 2021;134(7):814-820.

(17) Fang YY, Ji LL, Zhu CY, Xiao YY, Zhang JJ, Lu JX,Yin J* and Wei L*. Liraglutide Alleviates Hepatic Steatosis by Activating the TFEB-regulated Autophagy-lysosomal Pathway.Front Cell Dev Biol. 2020 Nov 27;8:602574.

(18) Alimujiang M, Yu XY, Yu MY, Hou WL, Yan ZH, Yang Y, Bao YQ,Yin J*. Enhanced liver but not muscle OXPHOS in diabetes and reduced glucose output by complex I inhibition.J Cell Mol Med.2020 May;24(10):5758-5771.

(19) Xiao Y, Xu M, Alimujiang M, Bao Y, Wei L*,Yin J*. Bidirectional regulation of adenosine 5' - monophosphate - activated protein kinase activity by berberine and metformin in response to changes in ambient glucose concentration.J Cell Biochem.2018 Dec;119(12):9910–9920.

(20) Ying LW, Ma XJ,Yin J*, Wang YF, He XX, Peng JH, Bao YQ, Zhou J, Jia WP. The metabolism and transport of 1,5-anhydroglucitol in cells.Acta Diabetol, 2018 Mar, 55(3):279–286.

(21) Hou WL,Yin J*, Alimujiang M, Yu XY, Ai LG, Bao YQ, Liu F*, Jia WP*. Inhibition of mitochondrial complex I improves glucose metabolism independently of AMPK activation.J Cell Mol Med. 2018 Feb, 22(2):1316-1328.

(22) Su H, Ma X,Yin J*, Wang Y, He X, Bao Y, Zhou J, Jia W. Serum 1,5-anhydroglucitol levels slightly increase rather than decrease after a glucose load in subjects with different glucose tolerance status.Acta Diabetol, 2017 May, 54(5):463-470.

(23) Xu M, Xiao Y,Yin J*, Hou W, Yu X, Shen L, Liu F, Wei L, Jia W. Berberine promotes glucose consumption independently of AMP-activated protein kinase activation.PLoS One, 2014 Jul 29;9(7):e103702.

(24) Yin J, Lee JH, Zhang J, Gao Z, Polotsky VY, Ye J. Regulation of hepatocyte growth factor expression by NF-κB and PPARγ in adipose tissue.Am J Physiol Endocrinol Metab. 2014 Apr 15;306(8):E929-36 .

(25) Yin J, Zhang F, Zhang H, Shen L, Li Q, Hu S, Tian Q, Bao Y, Jia W. Hand-Schüller-Christian disease and Erdheim-Chester disease: coexistence and discrepancy.Oncologist. 2013;18(1):19-24 .

(26) Yin J, Zuberi A, Gao Z, Liu D, Liu Z, Ye J: Shilianhua extract inhibits GSK-3β and promotes glucose metabolism.Am J Physiol Endocrinol Metab296(6), E1275-E1280, 2009 Jun.

(27) Yin J, Zhanguo G, He Q, Zhou D, Guo Z, Ye J: Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue.Am J Physiol Endocrinol Metab 296(2): E333–E342, 2009 Feb.

(28) Yin J, Zuberi A, Gao Z, Liu D, Liu Z, Cefalu W, Ye J: Effect of Shilianhua extract and its fractions on body weight of obese mice.Metabolism 57 (Suppl 1): S47-S51, 2008 Jul.

(29) Yin J*, Xing H, Ye J: Efficacy of berberine in patients with type 2 diabetes.Metabolism 57(5):712-7, 2008.

(30) Yin J, Gao Z, Liu D, Liu Z, Ye J: Berberine improves glucose metabolism through induction of glycolysis.Am J Physiol Endocrinol Metab 294(1):E148-156, 2008.

(31) Yin J, Hu R, Chen M, Tang J, Li F, Yang Y, Chen J: Effects of berberine on glucose metabolism in vitro.Metabolism 51(11):1439-1443, 2002.

著作教材：

(1)《临床内分泌学（第2版）》，上海科学技术出版社，2022，参编。

(2)《糖尿病防治路上指南针》，上海科学技术出版社，2016，参编。

授权专利：

(1) 殷峻，侯沃霖. 鱼藤酮在制备降血糖药物中的应用，2017年11月17日，中国，专利号：ZL201510439208.8。

获奖情况：

(1) 殷峻（1/10）, 从中焦论治2型糖尿病的中西医结合防治策略及机制，中国中西医结合学会，科学技术奖，三等奖，2024年；

(2) 殷峻（1/10），基于能量代谢的2型糖尿病中西医结合防治策略及机制研究，上海市中西医结合学会，科技奖，一等奖，2023年；

（3）殷峻（5/10），新时代背景下大学附属医院以胜任力为导向的临床教学模式的探索与实践，上海交通大学，教学成果奖，一等奖，2023年；

（4）殷峻（8/10），糖尿病防治路上的指南针和新鲜事，上海市科学技术普及奖，一等奖，2019年。

联系方式：

邮箱：yinjun@sjtu.edu.cn