个人简介:
屈延,男,1974年1月出生,博士学位,主任医师,教授,陕西中医药大学硕士研究生指导教师。现任空军军医大学第二附属医院神经外科主任,兼任中国医师协会神经外科分会副会长、中国医师协会胶质瘤专业委员会副主任委员、国家创伤中心颅脑创伤委员会副主任委员、中华医学会神经外科分会青委会副主任委员、中国神经科学学会神经外科学基础与临床分会副主任委员、陕西省医学会神经外科分会候任主任委员等职。
学习工作经历:
1997年07月本科毕业于第四军医大学,2001年7月硕士毕业于第四军医大学,2005年8月博士毕业于第四军医大学。先后在美国Thomas Jefferson大学、成都军区总医院神经外科、西京医院神经外科工作。
研究方向:
主要研究方向为颅脑创伤、脑卒中及脑肿瘤的综合临床救治及研究
承担主要在研课题:
(1) 国家自然科学基金重点项目《星形胶质细胞异质性在TBI远期恐惧记忆中的作用机制研究》2025-01至2029-12,在研,主持;
(2) 国家自然科学基金重点项目《反应性星形胶质细胞在血脑屏障损伤和修复中的作用机制研究》2022-01至2026-12,在研,主持。
(3) 国家自然科学基金重点项目《脂联素调节NLRP3 炎性小体在脑卒中后炎性损伤中的作用及机制研究》2017-01至2021-12,已结题。
(4) 军队高层次科技创新人才工程-拔尖人才-重点项目《颅脑**伤*****急救新技术研发》2022-01至2026-12在研,主持。
(5) 军队生物安全研究专项计划《高技术****重塑关键技术研究》2023-09至2025-12,在研,主持。
(6)国家重点研发计划子课题《脑胶质瘤液体活检分子标志物鉴定及临床应用》2023-11至2026-10,在研,主持。
近三年以通讯作者发表SIC论文情况:
(1) The m6A methyltransferase METTL3 drives neuroinflammation and neurotoxicity through stabilizing BATF mRNA in microglia。Cell Death Differ.2024 Jun 20.
(2) FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control。 Cell Death Dis . 2024 May 27;15(5):364.
(3) Risk factors for hemorrhage in patients with long-term aspirin therapy undergoing emergency external ventricular drainage/ intracranial pressure probe placement。 Heliyon. 2024;10(5):e26854.
(4) Trans-Defect Underlay Watertight Duraplasty for Traumatic Anterior Skull Base Dural Defect: Technical Report.World Neurosurg. 2024 Jun;186:1-6.
(5) Astrocyte-Derived Extracellular Vesicular miR-143-3p Dampens Autophagic Degradation of Endothelial Adhesion Molecules and Promotes Neutrophil Transendothelial Migration after Acute Brain Injury.Advanced Science.2023 Dec 3:e2305339
(6) Ferroptosis in Parkinson's Disease: Molecular Mechanisms and Therapeutic Potential Ageing research reviews;2023 :91:102077
(7) Targeted nutritional intervention with enhanced recovery after surgery for carotid endarterectomy: A prospective clinical trial Front Nutr.2023 Apr 13;10
(8) Analysis of risk factors and treatment strategies for lumbar cistern blockage after craniocerebral surgery Frontiers in Neuroscience.2023 February 28;17
(9) A pregnant woman with agiant bilateral parietal hemangiopericytoma underwent multiple surgeries and radiotherapy: a case report and literature review Frontiers in Oncology;2023; 24:13:1172143
(10) Knowledge structure and hotspots research of glioma immunotherapy: a bibliometric analysis Frontiers in Oncology;2023;21:13:1229905
(11) Clinical outcomes and safety of large or giant vestibular schwannoma in older patients undergoing microsurgery: a matched cohort study Journal of Neuro-Oncology;2023;164(2):501.
(12) An alternative extension of telomeres related prognostic model to predict survival in lower grade glioma Journal of Cancer Research and Clinical Oncology;2023 ;149(15):13575-13589.
(13) The incidence and risk factors of unplanned reoperation in endoscopic endonasal surgeries: a single center study.Neurosurgical Review;2023;4;46(1):224.
(14) Unruptured anterior Inferior cerebellar artery aneurysm following stereotactic irradiation for vestibular schwannoma: Case report and literature review Front Surg.2023 Feb 9;10:1082265.
(15) Salvation of Temporalis Muscle in Cranioplasty: A Technique Note World Neurosurg.2023 Apr 20;176:31-34
(16) A six-surface system to describe the anatomy of the anterior clinoid process and its application in anterior clinoidectomy and resection of paraclinoid meningiomas. World Neurosurgery;2023:178:e777-e790
(17) Precise location of the ventricular catheter tip in ventriculoperitoneal shuntplacement guided by 3D printed individualized guide.Clinical Neurology and Neurosurgery; 2023;229:107730
(18) Supratentorial Acute Subdural Hematoma During Fully Endoscopic Microvascular Decompression Surgery for Hemifacial Spasm.J Craniofac Surg.2023 Mar-Apr;34(2):e187-e190.
(19) Application of Neuronavigation in Microvascular Decompression: Optimizing Craniotomy and 3D Reconstruction of Neurovascular Compression The Journal of Craniofacial Surgery;2023 ;34(7):e620-e623
(20) Single-Nucleus RNA Sequencing Reveals that Decorin Expression in the Amygdala Regulates Perineuronal Nets Expression and Fear Conditioning Response after Traumatic Brain Injury.Advanced Science (Weinh). 2022 Mar;9(7):e2104112.
(21) Astrocytic ndrg2-ppm1a interaction exacerbates blood-brain barrier disruption after subarachnoid hemorrhage.Science Advances. 2022 Sep 30;8(39):eabq2423.
(22) Adiponectin/AdiopR1 signaling prevents mitochondrial dysfunction and oxidative injury after traumatic brain injury in a SIRT3 dependent manner. Redox Biol.2022 Aug;54:102390
(23) SLC1A5 enhances malignant phenotypes through modulating ferroptosis status and immune microenvironment in glioma.Cell Death Dis.2022 Dec 24;13(12):1071.
(24) MicroRNA-124/Death-Associated Protein Kinase 1 Signaling Regulates Neuronal Apoptosis in Traumatic Brain Injury via Phosphorylating NR2B.Front Cell Neurosci.2022 Jun 15;16:892197
(25) The Specific Role of Reactive Astrocytes in Stroke. Front Cell Neurosci.2022 Mar 7;16:850866
(26) Application of Subperineural Resection Technique in Vestibular Schwannomas: Surgical Efficacy and Outcomes in 124 patients. Front Oncol. 2022 Apr 20;12:849109
(27) Intracranial-Pressure-Monitoring-Assisted Management Associated with Favorable Outcomes in Moderate Traumatic Brain Injury Patients with a GCS of 9–11.J Clin Med.2022,11,6661.
(28) Association between Traumatic Subarachnoid Hemorrhage and Acute Respiratory Failure in Moderate-to-Severe Traumatic Brain Injury Patients. J Clin Med.2022 Jul 10;11(14):3995
(29) Predicting Neurological Deterioration after Moderate Traumatic Brain Injury: Development and Validation of a Prediction Model Based on Data Collected on Admission. J Neurotrauma.2022 Mar;39(5-6):371-378
(30) Pre-operative external ventricle drainage improves neurological outcomes for patients with traumatic intracerebellar hematomas. Front. Neurol.2022
专著情况:
(1)《颅脑放射影像解剖图谱》人民卫生出版社,2015,主译
(2)《神经外科手术解剖学》科学出版社,2022,主译
(3)《头部大事:神经外科科普书》中国轻工业出版社,2023,副主编
授权专利:
(1) 《拟脂联素多肽片段用于治疗缺血缺氧性脑病药物的应用》2014年1月,中国,ZL20101 0185120.5
(2) 《一种多功能解剖刀》2015年6月,中国ZL20131 0275470.4
(3) 《一种双极电凝器调控装置》2016年3月,中国ZL20152 0799519.0
(4) 《实验室用抗体孵育装置》2019年11月,中国ZL201921908945.8
(5) 《一种用于脑组织切片的脑槽专用刀片》2019年11月,中国ZL201921908944.3
(6) 《一种实验室用颅骨标本固定装置》2020年7月,中国ZL201921908451.X
(7) 《颅底手术用按压电凝型硬膜闭合装置》2021年7月,中国ZL202022653148.9
(8) 《一种多角度持控且组织损伤小的缝合针》2021年11月,中国ZL202120633829.0
(9) 《便携式去骨瓣减压术后颅内压无创快速检测装置及模型》2022年4月,中国ZL202120139643.X
(10)《颅内出血病灶CT形态特征定量化分析软件V1.0》,软著登字第6127077号,计算机软件著作权,2020
(11)《去骨瓣减压术后颅内压便携式监测系统V1.0》软著登字第6097250号,计算机软件著作权,2020
获奖情况:
(1) 脑深部电刺激治疗功能性脑病的技术创新及应用。陕西省科学技术进步一等奖,第一,2024年。
(2) 脑卒中综合救治新技术及其应用。陕西省科学技术奖一等奖,第一,2018年。
(3) 大黄及血红素加氧酶对创伤应激后神经元保护机制的研究。军队科技进步一等奖,第二,2008年。
(4) 第二十二届中国科协“求是”杰出青年奖,中国科学技术协会,2020年
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