个人简介：

杨浩，男，1971年10月17日出生，博士学历，博士学位，研究员职称，陕西中医药大学博士研究生指导教师。现任西安市红会医院转化医学中心主任，兼任中国脊髓脊柱损伤修复及残疾人康复医学会青年委员，中国康复医学会脊柱脊髓基础研究学委员，中华预防医学会脊柱脊髓基础研究学委员，美国神经科学会会员，ACSGC会员，中国神经科学学会会员，国际期刊Biomedicines, World journal stem cells, Therapeutic Targets for Neurological Diseases，Biocell, Biomedical Sci编委, J cell physiology, Cytotech、Stem cell Res、Stem cell Res and therapy、Brain Res Bulletin、BMC neuroscience、Inter J Neuroscience、Oncogene特邀审稿专家。

学习工作经历：

1994年7月本科毕业于军第四军医大学临床医学专业，2001年6月硕士研究生毕业于第四军医大学， 2007年6月博士研究生毕业于第四军医大学， 2009年-2011年在美国Emory University医学院从事博士后研究工作。先后在第四军医大学神经科学研究所，上海交通大学医学院仁济医院，美国Loma linda大学访问学者，西安交通大学附属红会医院工作，主要从事教学和科研工作。

研究方向：

干细胞治疗中枢神经退变性疾病与神经损伤修复的研究。

科研课题：

1) 国家自然科学基金面上项目，PBAE纳米颗粒介导促神经转录因子ASCL1和NGN2基因转导消融胶质瘢痕促脊髓再生的作用及分子机制，2021-01至2025-12，主持。

2) 国家自然科学基金面上项目，SHH缓释信号对OCT-4诱导星形胶质细胞向神经干细胞去分化的作用及分子调控机制. 2017-01至2020-12，已结题，主持。

3) 国家自然科学基金面上项目，嗅鞘细胞协同限定性生长因子诱导人精原干细胞转分化为多巴胺神经元的作用及分子调控机制; 2014-01至2017-12，已结题，主持。

4) 国家自然科学基金面上项目，星形胶质细胞在机械损伤后释放活性分子又到其逆分化为神经干细胞的分子机制，2010-01至2012-12，已结题，主持。

5) 陕西省自然科学基金面上项目，PCL负载SAP包裹激活态的OECs促脊髓损伤修复作用及机制2020-01至2022-12，已结题，主持。

6) 国家自然科学基金重点项目，基于SCI动态病理变化的多靶向治疗促脊髓再生修复及相关机制研究，2019-01至2023-12，已结题，骨干。

7) 宁夏自治区重点研发项目，脑脊髓损伤及退变的靶向消融胶质瘢痕转化研究2022-01至2025-12，主持，在研。

8) 西安市卫健委面上培育项目，ASCL1/NGN2基因转导调节Cend1/p53信号靶向诱导胶质瘢痕重编程为神经元促脊髓再生的研究2023-01至2025-12，在研，主持

9) 西安市科技局医学研究项目，纳米颗粒负载促神经转录因子靶向消融胶质瘢痕治疗脊髓损伤的研究2024-01至2026-12，在研，主持

发表论文（近5年*通讯）：

1) Jianbin Guo , Xiangwen Tang , Peng Deng , Hao Hui , Bo Chen , Jing An , Gaorong Zhang , Kuohao Shi , Jinchao Wang , Yuqing He , Dingjun Hao,Yang Hao* Interleukin-4 from curcumin-activated OECs emerges as a central modulator for increasing M2 polarization of microglia/macrophage in OEC anti-infammatory activity for functional repair of spinal cord injury.Cell Communication and Signaling. 2024; 22:162.

2) Xiangwen Tang , Peng Deng , Lin Li , Yuqing He, Jinchao Wang, Dingjun Hao,Hao Yang*. Advances in genetically modified neural stem cell therapy for central nervous system injury and neurological diseases. Stem Cell Research & Therapy. 2024.15:482. 

3) Jing An, Bo Chen, Rui Zhang, Ding Tian, Kuohao Shi, Lingling Zhang, GaoronZhang g, Jinchao Wang,Hao Yang*.Therapeutic potential of mesenchymal stem cell-derived exosomes in spinal cord injury. Mol Neurobiol. 2025;62(1):1291-1315.

4) Xingdong Zeng , Yongle Cai , Mengyan Wu, Haonan Chen , Miao Sun,Hao Yang*. An overview of current advances in perinatal alcohol exposure and pathogenesis of fetal alcohol spectrum disorders.Journal of Neurodevelopmental Disorders. 2024;16:20.

5) Beibei Xu, Hao Li, He Zheng , Zhongyu Gao, Zhigang Miao, Xingshun Xu, Hao Yang* , Yi Yang. Interleukin-18 interacts with NKCC1 to mediate brain injury after intracerebral hemorrhage.Brain Behav Immun Health. 2024 ; 42:100890.

6) Ma Xaohua, Xu Shiyao, Zhou Yaohui, Zhang Qian, Yang Hao, Wan Bo, Yang Yong, Miao Zhigang, Xuingshun X. Targeting Nr2e3 to Modulate Tet2 Expression: Therapeutic Potential for Depression Treatment.Adv Sci. 2024;11(31):e2400726.

7) Yuqing He, Yizhen Jiang, Lianwei Dong, Chao Jiang, Lingling Zhang, Gaorong Zhang,Hao Yang*, Juan Liu. The aOECs facilitate the neuronal differentiation of neural stem cells in the inflammatory microenvironment through up-regulation of bioactive factors and activation of wnt3/β-catenin pathway.Mol Neurobiol. 2023; 60(2):789-806.

8) Wang Bin, Shi Haixia, Yang Bo, Miao Zhigang, Sun Miao, Yang Hao*, Xu Xingshun. The mitochondrial Ahi1/GR participates the regulation on mtDNA copy numbers and brain ATP levels and modulates depressive behaviors in mice.Cell Commun Signal. 2023; 23;21(1):21

9) Tang Xiangwen, Deng Peng, Jiang Yizhen, Zhang Lingling, He Yuqing,Yang Hao*. An overview of recent advances in the neuroprotective potentials of fisetin against diverse insults in neurological diseases and the underlying signaling pathways.Biomedicines. 2023;11(11):2878

10) Jiang Yizhen, Tang Xiangwen, Deng Peng, Jiang Chao, He Yuqing, Hao Dingjun,Yang Hao*. The Neuroprotective Role of Fisetin in Different Neurological Diseases: a Systematic Review.Mol Neurobiol. 2023; 60(11):6383-6394.

11) Jiang Chao, Chen Zhe, Wang Xiaohui, Zhang Yongyuan, Guo Xiyu, Fan Hao, Huang Dageng, He Yuqing, Tang Xiangwen, Ai Yixiang, Liu Youjun,Yang Hao*, Hao Dingjun. Curcumin-activated olfactory ensheathing cells improve functional recovery after spinal cord injury by modulating microglia polarization through APOE/TREM2/NF-κB signaling pathway.J Neuroimmune Pharmacol.2023;18(3):476-494.

12) Chao Jiang, Zhe Chen, Xiaohui Wang, Yongyuan Zhang,Xinyu Guo, Zhengwei Xu,Hao Yang* and Dingjun Hao. The potential mechanisms and application prospects of non-coding RNAs in intervertebral disc degeneration.Front Endocrinol. 2022.13:1081185.

13) Zhe Chen, Hong Fan, ZiYi Chen, Chao Jiang, MingZhe Feng, XinYu Guo,Hao Yang* , DingJun Hao. OECs Prevented Neuronal Cells from Apoptosis Partially Through Exosome-derived BDNF.J Mol Neurosci. 2022 ;72(12):2497-2506

14) Hong Fan, Zhe Chen, Haibin Tang, Le-Qun Shan, Zi-Yi Chen, Shi-Chang Liu, Yong-Yuan Zhang, Xin-Yu Guo, Hao Yang* Dingjun Hao. Necroptosis of nucleus pulposus cells involved in intervertebral disc degeneration through MyD88 signaling. Front Endocrinol. 2022 Sep 21;13:994307.

15) Yizhen Jiang, Jianbin Guo, Xiangwen Tang, Xiaohui Wang, Dingjun Hao,Hao Yang*. The immunological roles of olfactory ensheathing cells in the treatment of spinal cord injury.Front Immunol. 2022; 13: 881162.

16) Chao Jiang, Xiaohui Wang, Yizhen Jiang, Zhe Chen, Yongyuan Zhang, Dingjun Hao,Hao Yang*. The Anti-inflammation Property of Olfactory Ensheathing Cells in Neural Regeneration After Spinal Cord Injury.Mol Neurobiol. 2022;59(10):6447-6459.

17) Yonglei Cai, Junliu Liu, Bin Wang, Miao Sun,Hao Yang*. Microglia in the Neuroinflammatory pathogenesis of alzheimer's disease and related therapeutic targets. Front Immunol. 2022 26;13:856376.

18) Yongyuan Zhang, Xiaohui Wang, Chao Jiang, Zhe Chen, Ni Shuangyang, Hong Fan, Zhiyuan Wang, Fang Tian, Jing An,Hao Yang*, Dingjun Hao. Rho Kinase Inhibitor Y27632 Improves Recovery After Spinal Cord Injury by Shifting Astrocyte Phenotype and Morphology via the ROCK/NF-κB/C3 Pathway.Neurochem Res. 2022;47(12):3733-3744.

19) Xiaohui Wang, Chao Jiang, Yongyuan Zhang, Zhe Chen, Hong Fan, Yuyang Zhang, Zhiyuan Wang, Fang Tian, Jing Li,Hao Yang*, Dingjun Hao*. The promoting effects of activated olfactory ensheathing cells on angiogenesis after spinal cord injury through the PI3K/Akt pathway.Cell & Bioscience. 2022; 12(1):23.

20) Hong Fan, Zhe Chen, Hai-Bin Tang3, Le-Qun Shan, Zi-Yi Chen, Xiao-Hui Wang, Da-Geng Huang, Shi-Chang Liu, Xun Chen,Hao Yang*, Dingjun Hao*. Exosomes derived from olfactory ensheathing cells provided neuroprotection for spinal cord injury by switching the phenotype of macrophages/microglia.Bioeng Transl Med. 2022; 7: e10287 

21) Jianbin Guo, Guoqing Yang, Yuqing He, Huiming Xu, Hong Fan, Jing An, Lingling Zhang, Rui Zhang, Guihua Cao, Dingjun Hao,Hao Yang*. Involvement of α7nAChR in the protective effects of genistein againstβ‑Amyloid‑Induced oxidative stress in neurons via a PI3K/Akt/Nrf2 pathway related mechanism.Cellular and Molecular Neurobiology. 2021 41(2):377-393.

22) Likui Lu, Xi Yu, Yonglei Cai, Miao Sun,Hao Yang*. Application of CRISPR/Cas9 in Alzheimer's Disease. Front Neurosci. 2021;21;15:803894

23) Bo Chen, Jing An, Yun-Shan Guo, Juan Tang, Jing-Jing Zhao, Rui Zhang,Hao Yang*.  Tetramethylpyrazine induces the release of BDNF from BM-MSCs through activation of the PI3K/AKT/CREB pathway.Cell Biol Int. 2021 45(12):2429-2442.

24)  Jing An, Bo Chen, Ding Tian, Yunshan Guo, Yuzhu Yan, Hao Yang* Regulation of Neurogenesis and Neuronal Differentiation by Natural Compounds. Current Stem Cell Research & Therapy. 2022;17(8):756-771.

25) Bo Chen, Jingjing Zhao, Rui Zhang, Lingling Zhang, Qian Zhang,Hao Yang*, Jing An*. Neuroprotective effects of natural compounds on neurotoxin-induced oxidative stress and cell apoptosis.Nutritional Neurosci. 2022; 25(5):1078-1099

26) An Jing, Chen Bo, Zhao Jingjing, Zhang Rui,Hao Yang*. Neuroprotective effects of natural compounds on LPS-induced inflammatory responses in microglia.Am J Transl Res 2020;12(6):2353-2378.

27) Guoqing Yang, Yuqing He,Hao Yang* The involvement of bioactive factors in the self-renewal and stemness maintenance of spermatogonial stem cells. Molecular and Cellular Biochemistry.2021; 476(4):1813-1823.

28) Yuqing He, Li Guo, Juan Ding, Haowen Lv, Quanrui Ma, Chen Li, Yu Shao, Qiang Liu, Chun Zhang,Hao Yang*, Juan Liu. Down-regulation of N-methyl-D-aspartate receptor subunits 1 affects neurogenesis of hippocampal neural stem cells.Biocell. 2021; 45(2):417-426.

29) LingLing Zhang,Hao Yang*. Promotive effects of tetrahydroxystilbene glucoside on the differentiation of neural stem cells from the mesencephalon into dopaminergic neurons.Neurosci Lett.2021; Jan 18;742:13552

30) Jianbin Guo, Guihua Cao, Guoqing Yang，Yumin Zhang, Yakang Wang, Wei Song, Yayong Xu, Tao Ma, Rui Liu, Qian Zhang, Dingjun Hao,Hao Yang*. Transplantation of activated olfactory ensheathing cells by curcumin strengthens regeneration and recovery of function after spinal cord injury in rats.Cytotherapy. 2020; 20(6):310-312.

31) Zhe Chen, Fan Hong, Zhiyuan Wang, Dingjun Hao,Hao Yang*. Spermatogonial stem cells are a promising and pluripotent cell source for regenerative medicine.Am J Transl Res 2020;12(11):7048-7059

32) Hao Yang*, Cuicui Liu, Hong Fan, Bo Chen, Dageng Huang, Lingling Zhang, Qian Zhang, Jing An, Jingjing Zhao, Yi Wang, Dingjun Hao. Sonic Hedgehog Effectively Improves Oct4-Mediated Reprogramming of Astrocytes into Neural Stem Cells.Mol Therapy. 2019; 27(8):1467-1482.

33) Hong Fan, Lequn Shan, Haibin Tang, Lequn Shan, Shichang Liu, Dageng Huang, Xun Chen, Zhe Chen, Ming Yang, Xinhua Yin,Hao Yang*, Dingjun Hao. Quercetin Prevents Necroptosis of Oligodendrocytes by Inhibiting Macrophages/Microglia Polarization to M1 Phenotype after Spinal Cord Injury in Rats.2019,J Neuroinflamm. 2019 16:206

34) Hao Yang*, Dingjun Hao, Cheng Liu, Dageng Huang, Bo Chen, Hong Fan, Cuicui Liu, Lingling Zhang, Qian Zhang, Jing An, Jingjing Zhao. Generation of functional dopaminergic neurons from human spermatogonial stem cells to rescue parkinsonian phenotypes.Stem Cell Research & Therapy. 2019; 10(1):195. 10.1186/s13287-019-1294-x

著作教材：

(1) 神经生物学实用实验技术手册，第四军医大学出版社， 2013，参编

授权专利：

(1)路凡，谢松涛，杨浩，一种重组多功能生长因子Pleioterophin融合蛋白及其制备方法，发明专利 2014年6月13， 中国，ZL 2013 10068275.4。

(2)杨浩， 唐香文，邓鹏，田丁，安婧，陈博，一种干细胞源外泌体的制备装置， 2024年3月24日，中国，ZL 2023 2 1867991.4。

获奖情况：

(1)杨浩（4/10）,脊柱损伤修复关键技术的基础与临床应用， 陕西科技进步一等奖，2015

 联系方式：

Yanghao71_99@yeah.net