个人简介：

奚苗苗，女，1977年7月21日出生，博士研究生学历，医学博士学位，副主任药师，陕西中医药大学硕士研究生指导教师。任陕西省中西医结合学会临床应用基础研究专业委员会副主任委员及青年委员会主任委员、中国环境诱变剂学会活性氧生物学效应专业委员会常委。

学习工作经历：

1998年6月本科毕业于中国人民解放军海军（原第二）军医大学，硕士毕业于中国人民解放军空军（原第四）军医大学，博士毕业于中国人民解放军空军军医大学，大学毕业后在中国人民解放军空军军医大学西京医院药剂科工作，主要从事科研、教学及临床合理用药工作二十余年。

研究方向：

心脑血管病、糖尿病、皮肤病治疗中药药效物质筛选、药物研发及合理使用。

科研课题：

(1) 国家自然科学基金，基于“药效物质配比-生物效应”回归模型研究丹参-降香配伍调控糖酵解-组蛋白乳酸化-血管新生治疗冠心病的作用机制，2025-01至2028-12，在研，主持；

(2) 国家自然科学基金，基于药效差示血清色谱法-代谢组学技术研究丹参-降香对药治疗冠心病的药效物质及作用机制，2015-01至2018-12，已结题，主持；

(3) 国家自然科学基金，楤木皂苷通过AMPK信号通路改善胰岛素抵抗的机制研究，2011-01至2013-12，已结题，主持。

发表论文：

(1) Liu CZ, Liu KD, Tao XR, Li WH, Zhao S, Dai Q, Yao H, Mu F, Chen S, Li J, Dong TW, Duan JL, Wei PF, Gao F,Xi MM^*. Pharmacodynamics and mechanism of Erigeron breviscapus granules in the treatment of ischemic stroke in mice by regulating sphingolipid metabolism based on metabolomics. Journal of Pharmaceutical and Biomedical Analysis. 2024, 242: 116058.

(2) Dai Q, Zhao S, Li WH, Liu KD, Tao XR, Liu CZ, Yao H, Mu F, Chen S, Li J, Wei PF, Gao F,Xi MM^*. Pharmacodynamics and mechanism of Astragali radix and Anemarrhenae rhizoma in treating chronic heart failure by inhibiting complement activation. Rejuvenation Research. 2024，27(2):61-74.

(3) Mu F, Zhao JX, Zhao MN, Lin R, Liu KD, Zhao S, Tao XR, Li WH, Dai Q,Xi MM^*, Tang HF, Wang JW. Styrax (Liquidambar orientalis Mill.) promotes mitochondrial function and reduces cardiac damage following myocardial ischemic injury: the role of the AMPK-PGC1α signaling pathway. Journal of Pharmacy and Pharmacology. 2023, 75(12):1496-1508.

(4) Tao XR, Liu KD, Li WH, Zhao S, Liu CZ, Dai Q, Dong TW, Wei PF, Duan JL, Wang JW,Xi MM^*. Saponin of Aralia taibaiensis promotes angiogenesis through VEGF/VEGFR2 signaling pathway in cerebral ischemic mice. JournalofEthnopharmacology. 2023, 317:116771.

(5) Li WH, Liu KD,Tao XR, Shi Z, Mu F, Chen S, Wang WY, Li J,Lu XM, Bai Y, Hou L, Duan JL, Wei PF,Xi MM^*. Applicationof mixture design for optimum cardio protection efficacy of mixtures of salvianolic acid A.salvianolic acid B and danshensu from Salvia miltiorrhizaJ. Industrial Crops & Products.2023, 192:116095.

(6) Liu KD, Tao XR, Su J, Li F, Mu F, Zhao S, Lu XM, Li J.Chen S,Dong TW, Duan JL,Wei PF,Xi MM^*. Networkpharmacology and molecular docking reveal the effective substances and activemechanisms of Dalbergia Odorifera in protecting against ischemic stroke. PLoS One. 2021, 16(9):e0255736.

(7) Zhao MN, Jian YF, Li F, Su J，Duan JL, Mu F, Lin R, Bian HX, Wang XP, Yang HY, Lu XM, Wang J,Xi MM^*, Wen AD, Li J. Salvianolic acid B regulates macrophage polarization in ischemic/reperfused hearts by inhibiting mTORC1-induced glycolysis. European Journal of Pharmacology. 2020, 871:172916.

(8) Li F, Duan JL, Zhao MN, Huang SJ, Mu F, Su J, Liu KD, Pan Y, Lu XM, Li J, Wei PF,Xi MM^*, Wen A. A network pharmacology approach to reveal the protective mechanism of Salvia miltiorrhiza-Dalbergia odorifera coupled-herbs on coronary heart disease. Scientific Reports. 2019, 9(1):19343.

(9) Lin R, Duan JL, Mu F, Bian HX, Zhao MN, Zhou M, Li Y, Wen AD, Yang Y,Xi MM^*. Cardioprotective effects and underlying mechanism of Radix Salvia miltiorrhiza and Lignum Dalbergia odorifera in a pig chronic myocardial ischemia model. International Journal of Molecular Medicine. 2018, 42(5):2628-2640.

(10) Guo C, Wang SQ, DuanJL, Jia N, Zhu YR, Ding Y , Guan Y , Wei G , YinY ,Xi MM^*, WenAD. Protocatechualdehyde Protects against Cerebral Ischemia-Reperfusion-Induced Oxidative Injury via Protein Kinase Cε/Nrf2/HO-1 Pathway. Molecular Neurobiology.2017, 54(2): 833-845.

(11) Duan JL, Guan Y, Mu F, Guo C, Zhang EH, Yin Y, Wei G, Zhu YR, Cui J, Cao JY, Weng Y, Wang Y,Xi MM*, Wen AD. Protective effect of butin against ischemia/reperfusion-induced myocardial injury in diabetic mice: involvement of the AMPK/GSK-3β/Nrf2 signaling pathway. Scientific Reports. 2017,7:41491.

(12) Guo C, Ma YY, Ma SB, Mu F,  Deng J, Duan Jl, Xiong LZ, Yin Y, Wang YH,Xi MM^*, Wen AD. The role of TRPC6 in the neuroprotection of calycosin against cerebral ischemic injury. Scientific Reports, 2017, 7(1):3039.

(13) Yin Y, Duan J, Guo C, Wei G, Wang YH, Guan Y, Mu F, Yao M,Xi MM^*, Wen AD. Danshensu accelerates angiogenesis after myocardial infarction in rats and promotes the functions of endothelial progenitor cells through SDF-1α/CXCR4 axis.European Journal of Pharmacology. 2017, 814: 274-282.

(14) Wei G,Yin Y, Duan JL, Guo C, Zhu YR, Wang YH,Xi MM^*, Wen AD. Hydroxysafflor yellow A promotes neovascularization and cardiac function recovery through HO-1/VEGF-A/SDF-1α cascade. Biomedicine & Pharmacotherapy. 2017, 88: 409-420.

(15) Bian HX, Yang QL, Ma T, Li W, Duan JL, Wei G, Wu XX, Mu F, Lin R, Wen AD,Xi MM^*.Beneficial effects of extracts from Lucilia sericata maggots on burn wounds in rats. Molecular Medicine Reports. 2017, 16(5): 7213-7220.

(16) Mu F, Duan JL, Bian HX, Zhai XH, Shang PJ, Lin R1, Zhao MN, Hu DM, Yin Y, Wen AD,Xi MM^*.Metabonomic strategy for the evaluation of Chinese Medicine Salvia miltiorrhiza and Dalbergia odorifera Interferingwith myocardial ischemia/reperfusion injury in rats.Rejuvenation Res. 2017, 20(4): 263-277.

(17) Mu F, Duan JL, Bian HX, Yin Y, Zhu YR, Wei G, Guan Y, Wang YH, Guo C, Wen AD, Yang Y,Xi MM^*.Cardioprotective effects and mechanism of Radix Salviae miltiorrhizae and Lignum Dalbergiae odoriferae on rat myocardial ischemia/reperfusion injury. Molecular Medicine Reports. 2017, 16(2): 1759-1770.

(18) Duan JL, Ying Y, Cui J,Yan JJ, Zhu YR, Guan Y, Wei G, Weng Y, Wu XX, Guo C, Wang YH,Xi MM^*, Wen AD.Chikusetsu saponin IVaameliorates cerebral ischemia reperfusion injury in diabetic mice via adiponectin-mediated AMPK/GSK-3β pathway in vivo and in vitro. Molecular Neurobiology. 2016; 53(1):728-743.

(19) Duan JL, Yin Y, Wei G, Cui J, Zhang EH, Guan Y, Yan JJ, Guo C, Zhu YR, Mu F, Weng Y, Wang YH, Wu XX,Xi MM^*, Wen AD. Chikusetsu saponin IVa confers cardioprotection via SIRT1/ERK1/2 and Homer1a pathway. Scientific Reports. 2015, 5:18123.

(20) Duan JL, Wei G, Guo C, Cui J, Yan J, Yin Y, Guan Y, Weng Y, Zhu YR, Wu XX, Wang YH,Xi MM^*, Wen AD.Aralia taibaiensis Protects Cardiac Myocytes against High Glucose-Induced Oxidative Stress and Apoptosis. The American Journal of Chinese Medicine. 2015, 43(6):1159-1175

(21) Guan Y, Wu XX, Duan JL, Yin Y, Guo C,Wei G, Wang YH,Zhu YR,Weng Y,Xi MM^*, Wen AD.Effects and mechanism of combinationof rhein and danshensu in the treatmentof chronic kidney disease. The American Journal of Chinese Medicine. 2015, 43(7):1381-1400.

(22) Guo C, Yin Y, Duan JL, Zhu YR, Yan JJ, Wei G, Guan Y, Wu XX, Wang YH,Xi MM^*, Wen AD. Neuroprotective effect and underlying mechanism of sodium danshensu [3-(3,4-dihydroxyphenyl) lactic acid from Radix and Rhizoma Salviae miltiorrhizae =Danshen] against cerebral ischemia and reperfusion injury in rats. Phytomedicine. 2015, 22(2):283-289.

(23) Wu XX, Guan Y,Yan JJ, Liu MY, Yin Y, Duan JL, Wei G, Hu TX, Weng Y,Xi MM^*, Wen AD. ShenKang injection suppresses kidney fibrosis and oxidative stressvia TGF-β/Smad3signaling pathway in vivo and in vitro. Journal of Pharmacy and Pharmacology. 2015, 67(8):1054-1065.

(24) Li YW, Zhang TJ, Cui J, Jia N, Wu Y,Xi MM^*, Wen AD. Chikusetsu saponin IVaregulates glucose uptake and fattyacid oxidation: implications in antihyperglycemic andhypolipidemic effects. Journal of Pharmacy and Pharmacology. 2015, 67(7):997-1007.

(25) Yan JJ, Duan JL, Wu XX, Guo C,Yin Y, Zhu YR, Hu TX, Wei G, Wen AD,XiMM^*. Total saponins from Aralia taibaiensis protect against myocardial ischemia/reperfusion injury through AMPK pathway.International Journal of Molecular Medicine. 2015,  36(6):1538-1546.

(26) Guo C, Zhu YR, Weng Y, Wang SX, Guan Y, Wei G, Yin Y,Xi MM*, Wen AD*.Therapeutic time window and underlying therapeutic mechanism of breviscapine injection against cerebral ischemia/reperfusion injury in rats.Journal of Ethnopharmacology. 2014, 151(1):660-666.

(27) Weng Y, Yu L, Cui J, Zhu YR, Guo C, Wei G, Duan JL, Yin Y, Guan Y, Wang YH, Yang ZF,Xi MM^*, Wen AD. Antihyperglycemic, hypolipidemic and antioxidant activities of total saponins extracted from Aralia taibaiensis in experimental type 2 diabetic rats. Journal of Ethnopharmacology. 2014, 152(3): 553-560.

(28) Yin Y, Guan Y, Duan JL, Wei G, Zhu YR, Quan W, Guo C, Zhou D, Wang YH,Xi MM^*, WenAD. Cardioprotective effect of Danshensu against myocardial ischemia/reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation. European Journal of Pharmacology. 2013, 699(1-3):219-226.

(29) Duan JL, Wang JW, Guan Y, Yin Y, Wei G, Cui J, Zhou D, Zhu YR, Quan W,Xi MM^*, Wen AD. Safflor yellow A protects neonatal rat cardiomyocytes against anoxia/reoxygenation injury in vitro. Acta Pharmacologica Sinica. 2013, 34(4): 487-495.

(30) Cui J, Li YW, Jia N, Song XM, Duan JL, Weng Y, Guan Y, Zhou D, Wang L,Xi MM^*, Wen AD. Insulin-secretagogue activity of eleven plant extracts and twelve pure compounds isolated from Aralia taibaiensis. Life Sciences. 2013, 92(2):131-136.

(31) Wei G, Guan Y, Yin Y, Duan JL, Zhou D, Zhu YR, Quan W,XiMM^*,WenAD.Anti-inflammatory effect of protocatechuic aldehyde on myocardial ischemia/reperfusion injury in vivo and in vitro. Inflammation.2013, 36(3): 592-602.

(32) Quan W, Wei G, Zhou D, Zhu YR, Guo C, Wang YH, Weng Y,Xi MM^*, Wen AD.Magnesium lithospermate B reduces myocardial ischemia/reperfusioninjury in rats via regulating the inflammation response. Pharmaceutical Biology. 2013, 51(11): 1355-1362.

(33) Wang C, Xiao Q, Li YW, Yang ZF, Wu Y , Jia YY, Qiao Y,XiMM^*, Wen AD. Pharmacodynamic differential serum chromatography for Identifying the pharmacodynamic Material Basis of a traditional Chinese medicine. Chromatographia. 2012,  75(19): 1129-1134.

(34) Xi MM, Hai CX, Tang HF, Wen AD, Chen HL, Liu R, Liang X, Chen MS.Antioxidant and antiglycation properties of triterpenoid saponins from Aralia taibaiensis traditionally used for treating diabetes mellitus. Redox Report. 2010, 15(1): 20-28.

(35) Xi MM, Hai CX, Tang HF, Chen MS, Fang KQ, Liang X. Antioxidant and antiglycation properties of total saponins extracted from traditional Chinese medicine used to treat diabetes mellitus. Phytotherapy Research. 2008, 22(2): 228-237.

(36) Xi MM, Zhang SQ, Wang XY, Fang KQ, Gu Y.Study on the characteristics of pectin-ketoprofen for colon targeting in rats. International Journal of Pharmaceutics. 2005, 298(1): 91-97.

著作教材：

(1) 《小儿心脏病用药手册》，科学出版社， 2022，副主译；

(2) 全国临床药师规范化培训系列教材《妇产专业》，人民卫生出版社，2020，主编 ；

(3) 全国临床药师规范化培训系列教材《神经内科专业》，人民卫生出版社，2017，副主编；

(4) 《药物相互作用原理与临床应用指南》，人民军医出版社，2011，副主译。

获奖情况：

(1) 奚苗苗（1/6），基于类器官技术的肿瘤精准治疗及生物样本库建设，陕西省退役军人事务厅，创新奖，一等奖，2024；

(2) 奚苗苗（2/9），活血三法抑制炎性相关损伤的心肌保护机制及临床验证，中国中西医结合学会，科学技术奖，三等奖，2021；

(3) 奚苗苗（2/11），秦巴山区特产药材太白楤木皂苷药理学研究及应用，陕西省人民政府，科学技术奖，二等奖，2017；

(4) 奚苗苗（7/14），二仙汤防治骨质疏松症的基础及其临床转化应用，国家教育部，科技进步奖，二等奖，2015。

联系方式：

ximiaomiao@fmmu.edu.cn