个人简介

陈钧，男，1983.09出生。第四军医大学博士学位学历。主任医师，陕西中医药大学硕士研究生指导教师。陕西省中医医院脑病科副主任，陕西省特支计划青年拔尖人才。陕西省青年科技新星。陕西省青年五四奖章。陕西省中医药科研创新人才。入选国家中医药管理局国际交流人才。主持国家自然科学基金等多项。在《Journal of pineal research》《Heart rhythm》等发表SCI论文20余篇。

学习工作经历：

2012至今：陕西省中医医院脑病科  主任医师

2014/02 - 2015/02:  赴美国北卡罗来纳州立大学访问学者

2009/09 - 2012/06：第四军医大学，西京医院中西医结合专业，博士学位  

2001/09 - 2008/07：北京中医药大学，中医临床七年制，硕士学位

研究方向：中医药调节生物节律在防治精神病及神经退行性疾病中的作用机制研究。

科研课题：

1.陕西省中医药管理局，SZY-KJCYC—2025-LC-001, 基于心主血脉探索心血管节律变化与卒中后抑郁的相关性。2025-2026，10万，在研，主持

2.陕西省中医药科研创新人才项目，TZKN-CXRC-07,基于春夏养阳秋冬养阴探索后爱迪生时代的睡眠养生之道。2025-2026，20万，在研，主持

发表论文：

（1） He X, Zhang R, Li Z, Yao Z, Xie X, Bai R, Li L, Zhang X, Zhang S, Shen Y, Li S, Hui Z, Liu R,Chen J. Sini powder with paroxetine ameliorates major depressive disorder by modulating circadian rhythm: A randomized, double-blind, placebo-controlled trial. J Pineal Res. 2022 Sep 8:e12832. doi: 10.1111/jpi.12832. Epub ahead of print. PMID: 36073608.

（2） Cheng N, Liu J, Kan X, Wang J, Hui Z, Chen J. Optimizing Epilepsy Treatment: The Impact of Circadian Rhythms and Medication Timing on Conversion Rates and Survival. QJM. 2024 Aug 21:hcae167. doi: 10.1093/qjmed/hcae167. Epub ahead of print. PMID: 39167097.

（3） Cheng, N., Bai, R., Li, L., Zhang, X., Kan, X., Liu, J., …Chen, J. (2024). The influence of biological rhythms on the initial onset of status epilepticus in critically ill inpatients and the study of its predictive Model. Chronobiology International, 1–13. https://doi.org/10.1080/07420528.2024.2351490

（4） Yang Z, Xie X, Zhang X, Li L, Bai R, Long H, Ma Y, Hui Z, Qi Y,Chen J. Circadian rhythms of vital signs are associated with in-hospital mortality in critically ill patients: A retrospective observational study. Chronobiol Int. 2023 Jan 3:1-10. doi: 10.1080/07420528.2022.2163656. Epub ahead of print. PMID: 36597185.

（5） Yao Z, Xie X, Bai R, Li L, Zhang X, Li S, Ma Y, Hui Z,Chen J. The impact of eating behaviors during COVID-19 in health-care workers: A conditional process analysis of eating, affective disorders, and PTSD. Heliyon. 2022 Oct;8(10):e10892. doi: 10.1016/j.heliyon.2022.e10892. Epub 2022 Oct 4. PMID: 36211998; PMCID: PMC9529342.

（6） Yang Z, Li Z, He X, Yao Z, Xie X, Zhang S, Shen Y, Li S, Qiao S, Hui Z, Gao C, Chen J. The impact of heart rate circadian rhythm on in-hospital mortality in patients with stroke and critically ill: Insights from the eICU Collaborative Research Database. Heart Rhythm. 2022 Aug;19(8):1325-1333.

（7） Xu He, Nanding Wang, Zhe Li, Sha Zhang, Zhen Yao, Xiaoxia Xie, Zhengning Yang, Shuzhen Qiao, Zhenliang Hui,Jun Chen & Xia Du. Network pharmacology and GEO database-based analysis of Sini powder in the prevention of depression among shift workers. ALL LIFE. 15(1):74–87,(2022)

（8） Zhang L, Zhang R, Shen Y, Qiao S, Hui Z, Chen J. Shimian granules improve sleep, mood and performance of shift nurses in association changes in melatonin and cytokine biomarkers: a randomized, double-blind, placebo-controlled pilot study. Chronobiol Int.37（4）:592-605,（ 2020）

（9） Nanding Wang,, Xiaofeng Zhang,, Zhen Ma, Jinghu Niu, Shihang Ma, Wang Wenjie,Jun Chen,*  Combination of tanshinone IIA and astragaloside IV attenuate atherosclerotic plaque vulnerability in ApoE(-/-) mice by activating PI3K/ AKT signaling and suppressing TRL4/NF-κB signaling，Biomedicine & Pharmacotherapy 123（2020） 

（10） He X, Du X,Chen J. Study on the molecular mechanism of Guipi decoction against sleep deprivation based on integrated pharmacology analysis and gene expression profiling. Acta Neurobiol Exp (Wars). 2022;82(4):409-423. doi: 10.55782/ane-2022-039. PMID: 36748964.

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