郑敏文

个人简介：

郑敏文，女，1970年08月26日出生，研究生学历，博士学位，主任医师、教授，陕西中医药大学硕士研究生指导教师。现任空军军医大学第一附属医院（西京医院）放射科主任，兼任中华医学会放射学会常委兼心胸学组组长，中国医师协会放射医师分会常委兼急诊工作组组长，陕西省医师协会放射医师分会会长、陕西省医学会放射学分会副主委、国际心血管CT协会中国区论坛副主委、《中华放射学杂志》编委、《实用放射学杂志》副主编等社会任职。

学习工作经历：

1992年07月本科毕业于原第四军医大学，硕士毕业于第四军医大学，博士毕业于第四军医大学，毕业后一直在西京医院放射科工作，主要从事心血管疾病的影像诊断工作26年。

研究方向：

冠心病的精准影像诊断、风险预后评估及人工智能

科研课题：

 

（1）国家自然科学基金，心肌病变及易损斑块在冠心病心源性猝死中的CT/MR影像学机制对比及风险预测研究，2024-01至2027-12.31，在研，主持

（2）国家重点研发计划项目子课题，医生诊询引导的快速智能磁共振成像系统临床应用，2022-12至2027-11，在研，主持

（3）国家卫生健康委能力建设和继续教育中心放射影像数据库建设项目，主动脉夹层CT影像标准化数据库的构建，2022-04至2024-04，在研，主持

（4）陕西省秦创原“科学家+工程师”队伍建设项目，医学影像全自动诊断机器人的研发“科学家+工程师”队伍”，2022-01至2024.12，已结题，主持

（5）陕西省高等教育教学改革研究项目，“XR+5G+AI”技术在影像医师继续教育中的融合创新应用，2021-10至2023.10，已结题，主持

（6）国家自然科学基金，基于CT影像组学和计算流体力学的斑块形态学特征在冠状动脉解剖学狭窄与心肌缺血不匹配中的作用及机制研究，2021-01至2024-12，已结题，主持

（7）陕西高等教育教学改革研究项目-重点项目，在职影像医师人才培养模式“三改联动”的研究与实践，2019-12至2021.08，已结题，主持

（8）陕西省重点研发计划项目，冠状动脉高危斑块无创性早期识别和对不同人群风险分层的影像评价体系研究，2020-01至2022-12，已结题，主持

（9）陕西省重点研发计划项目一般项目-社会发展领域，头-颈-主动脉CT多模态成像指导急性主动脉A型夹层的精准治疗2017-01至2018-12，已结题，主持

（9）国家自然科学基金，基于仿真流体力学建立冠状动脉缺血性狭窄双能量CT功能评价指标的实验与临床研究，2015-01至2018-12，已结题，主持

（10）陕西省社会发展攻关计划课题，双源CT新技术的低剂量临床应用研究，2013-01至2014-12，已结题，主持

（11）国家自然科学基金面上项目，干细胞VEGF修饰后移植治疗心肌梗死的MRI活体基因成像研究，2010-01至2012-12，已结题，主持

发表论文：

（1）Zhu Yuanqiang#, Wang Chen#, Xu Ziliang#, Guo Fan, Chang Yingjuan, Liu Jiali, Liu WenMing, Fang Peng*, Zheng Minwen*. Individualized rTMS Intervention Targeting Sleep Deprivation-Induced Vigilance Decline: Task fMRI-Guided Approach. CNS Neuroscience & Therapeutics.2024 Nov;30(11):e70087.

（2）Yang Wenxuan#, Wen Didi#, Li Shuangxin, Zhao Hongliang, Xu Jijing, Liu Jianli, Chang Yingjuan, Xu Jian, Zheng Minwen*. Prognostic Value of Non-alcoholic Fatty Liver Disease and RCA Pericoronary Adipose Tissue CT Attenuation in Patients with Acute Chest Pain. Academic Radiology. 2024 May;31(5):1773-1783.

（3）Zhao Hongliang#, Li Chengxiang#, Duan Weixun, Wei Didi, Xue Ruijia, Wei Mengqi, Chang Yingjuan, Shang Lei, Lin Shushen, Xu Jian, Zheng Minwen*. Neurological prognosis in surgically treated acute aortic dissection with brain computed tomography perfusion. European Journal of Cardio-Thoracic Surgery. 2024 Jan 2;65(1):ezad437.

（4）Liu Jiali#, Zhu Yuanqiang#, Chang Yingjuan#, Xu Ziliang, Wang Chen, Zhang Pengpeng, Li Shuangxin, Yang Wenxuan, An Rui, Wen Didi, Xu Jian*, Zheng Minwen. Association of Objective Sleep Characteristics and Incident Angina Pectoris: A Longitudinal Analysis from the Sleep Heart Health Study. Nature and Science of Sleep. 2023 Nov 22;15:955-965.

（5）Zhao Hongliang#, Li Chengxiang#, Jin Zhenxiao, Duan Weixun, Shang Lei, Chang Yingjuan, Xu Jingji, Ren Jialiang, Lin Shushen, Wang Yan, Zhu Li, Wang Gang, Chen Xin, He Chao, Zheng Minwen*. Risk prediction of preoperative acute ischemic stroke in acute type A aortic dissection. European Radiology. 2023 Oct;33(10):7250-7259.

（6）Xue Ruijia#, Ren Zilong#, Zhao Honglaing, Xu Jingji, Li Shuanxin, Lin Shushen, Li Jiayi, Wen Didi*, Zheng Minwen*. Prognostic value of coronary CT angiography and CT myocardial perfusion imaging among patients with and without Diabetes. European Journal of Radiology. 2023 Oct;167:111063.

（7）Wen Didi#, Ren Zilong#, Xue Ruijia#, An Rui, Xu Jian, Jiayi Li*, Minwen Zheng*. Lack of incremental prognostic value of PCAT CT attenuation beyond CAD-RADS for major adverse cardiovascular events in patients with acute chest pain. Circulation Cardiovascular Imaging. 2023 Jul;16(7):536-544.

（8）Ren Zilong#, Wen Didi#, Xue Ruijia, Li Shuangxin, Wang Jing, Li Jiayi, Wang Qiong*, Zheng Minwen* Nonalcoholic fatty liver disease is associated with myocardial ischemia by CT myocardial perfusion imaging, independent of clinical and coronary CT angiography characteristics. European Radiology. 2023 Jun;33(6):3857-3866.

（9）Shu Jun, Wen Didi, Xu Ziliang, Meng Xiaoli, Zhang Zhixiang, Lin Shushen, Zheng Minwen*. Improved interobserver agreement on nodule type and Lung-RADS classification of subsolid nodules using computer-aided solid component measurement. European Journal of Radiology. 2022 Jul;152:110339.

（10）Xu Ziliang#, Zhu Yuanqiang#, Zhao Hongliang, Guo Fan, Wang Huaning*, Zheng Minwen*. Sleep stage classification based on multi-centers: comparison between different ages, mental health conditions and acquisition devices. Nature and Science of Sleep. 2022 May 24;14:995-1007.

（11）Wang Chen#, Fang Peng#, Li Ya, Wu L, Hu Tian, Yang Qi, Han Aiping, Chang Yingjuan, Tang Xing, Lv Xiuhua, Xu Ziliang, Xu Yongqiang, Li Leilei, Zheng Minwen*, Zhu Yuanqiang*. Predicting Attentional Vulnerability to Sleep Deprivation: A Multivariate Pattern Analysis of DTI Data. Nature and Science of Sleep. 2022 Apr 22;14:791-803.

（12）Wen Didi#, An Rui#, Lin Shushen, Yang Wangwei, Jia Yuyang, Zheng Minwen*. Influence of Different Segmentations on the Diagnostic Performance of Pericoronary Adipose Tissue. Frontiers in Cardiovascular Medicine. 2022 Mar 3;9:773524.

（13）Wen Didi#, Xu Ziliang#, An Rui, Ren Jia, Jia Yuyang, Li Jian, Zheng Minwen*. Predicting haemodynamic significance of coronary stenosis with radiomics-based pericoronary adipose tissue characteristics. Clinical Radiology. 2022 Feb;77(2):e154-e161.

（14）Liu Bing#, Sun Zhen#, Xu Ziliang, Zhao Honglaing, Wen Didi, Li Yongai, Zhang Fan, Hou Bingxin, Huan Yi, Wei Lichun, Zheng Minwen*. Predicting Disease-Free Survival With Multiparametric MRI-Derived Radiomic Signature in Cervical Cancer Patients Underwent CCRT. Frontiers in Oncology. 2022 Jan 25;11:812993.

（15）Zhao Hongliang, Xu Ziliang#, Zhu Yuanqiang, Xue Ruijia, Wang Jing, Ren Jialiang, Wang Wenjia, Duan Weixun, Zheng Minwen*. The Construction of a Risk Prediction Model Based on Neural Network for Pre-operative Acute Ischemic Stroke in Acute Type A Aortic Dissection Patients. Frontiers in Neurology. 2021 Dec 23;12:792678.

（16）Wen Didi, Zhao Hongliang, Zhong Sihua, Li Chenwei, An Rui, Liu Bing, Li Jiayi, Zheng Minwen*. Diagnostic performance of corrected FFRCT metrics to predict hemodynamically significant coronary artery stenosis. European Radiology. 2021 Dec;31(12):9232-9239.

（17）Wen Didi#, Li Jiayi#, Ren Jialiang, Zhao Hongliang, Li Jian, Zheng Minwen*. Pericoronary adipose tissue CT attenuation and volume: diagnostic performance for hemodynamically significant stenosis in patients with suspected coronary artery disease. European Journal of Radiology. 2021 July 140: 109740.

（18）Zhao Hongliang#, Guo Fan#, Xu Jijing, Zhu Yuanqiang, Wen Didi, Duan Weixun, Zheng Minwen*. Preoperative imaging risk findings for postoperative new stroke in patients with acute type A aortic dissection. Frontiers in Cardiovascular Medicine. 2020 Nov 30; 7:602610.

（19）Zhu Yuangqing#*, Ren Fang#, Zhu Yuanju#, Zhang Xiao, Liu Wenming, Tang Xing, Qiao Yuting, Cai Yanhui, Zheng Minwen*. Gradually increased interhemispheric functional connectivity during one night of sleep deprivation. Nature and Science of Sleep. 2020 Nov 23; 12:1067-1074.

（20）Liu Bing, Sun Zhen, Ma Wanling, Ren Jing, Zhang Guangwen, Wei Mengqi, Hou Weihuan, Hou Bingxin, Wei Lichun, Huan Yi*, Zheng Minwen*. DCE-MRI quantitative parameters as predictors of treatment response in patients with locally advanced cervical squamous cell carcinoma underwent CCRT. Frontiers in Oncology. 2020 Oct 29; 10:585738.

（21）Xie Xinzhou, Wen Didi, Zhang Ruichen, Tao Qian, Wang Ce, Xie Songyun, Liu Hui*, Zheng Minwen*. Pressure-flow curve derived from coronary CT angiography for detection of significant hemodynamic stenosis. European Radiology. 2020 Aug;30(8):4347-4355.

（22）Zhao Hongliang#, Ma Wanling#, Wen Didi, Duan Weixun, Zheng Minwen*. Computed tomography angiography findings predict the risk factors for preoperative acute ischaemic stroke in patients with ATAAD. European Journal of Cardio-Thoracic Surgery. 2020 May 1;57(5):912-919. 

（23）Wen Didi, Xu Jian, Huan Yi, Wei Mengqi*, Zheng Minwen*. Effects of endothelial progenitor cells applied for autograft transplantation in a pig model of acute myocardial infarction. Cardiovascular Imaging Visa. 2018 Jul, 2(3): 142-149.

（24）Zhao Hongliang, Wen Didi, Duan Weixun, An Rui, Li Jian, Zheng Minwen*. Identification of CTA-based predictive findings for temporary and permanent neurological dysfunction after repair in acute type A aortic dissection. Scientific Reports. 2018 Jun 27, 8(1): 9740.

（25）Wen Didi#, Li Jiayi#, Zhao Hongliang, Li Jian, Zheng Minwen*. Diagnostic performance of two corrected transluminal attenuation gradient metrics in coronary CT angiography for the evaluation of significant in-stent restenosis by dual-source CT: a validation study with invasive coronary angiography. Clinical Radiology. 2018 Jun, 73(6): 592.e1-592. e8.

（26）Wen Didi#, Wang Zhankui#, Yu Jing#, Zhang Wenlong, Yang Xiaobin, He Hua, Zhang Xuexin, Lin Ying, An Rui, Zheng Minwen*, Xu Jian*. Endovascular stent-graft repair of spontaneous isolated dissection of the superior mesenteric artery. Cardiovascular and Interventional Radiology. 2018 May, 41(5): 692-698.

（27）Wen Didi, Xu Jian, Liu Ying, An Rui, Li Jian, Zhao Hongliang, Zheng Minwen*. The effect of without using anisodamine during CT enterography on image quality, diagnostic performance and latent side effects. Clinical Imaging. 2018 Mar-Apr; 48: 106-112.

（28）Xu Jian, Zheng Zhao, Yang Yong, Zhang Wenlong, Zhao Hongliang, E Bei, Zheng Minwen*. Clinical evaluation of covered stents in the treatment of superficial femoral artery pseudoaneurysm in drug abusers. Molecular Medicine Reports. 2018 Mar;17(3):4460-4466.

（29）Wen Didi, Zhao Hongliang, Duan Weixun, An Rui, Li Jian, Zheng Minwen*. Combined CT Angiography of the aorta and craniocervical artery: A new imaging protocol for assessment of acute type A aortic dissection. Journal of Thoracic Disease. 2017 Nov, 9(11): 4733-4742.

（30）Liu Ying, Li Jian, Zhao Hongliang, Jia Yan, Ren Jing, Xu Jian, Hao Yuewen, Zheng Minwen*. Image quality and radiation dose of dual-source CT cardiac angiography using prospective ECG-triggering technique in pediatric patients with congenital heart disease. J Cardiothoracic Surgery. 2016 Apr 9, 11:47.

（31）Ma Jian#, Zhang Hongmei#, Zhang Liwang, Zheng Minwen*, Yu Min*. Primary mediastinal giant liposarcoma with smooth muscle and neural differentiation: a case report. Oncol Lett. 2015 Jun, 9(6):2667-2669.

（32）Zheng Minwen*#, Wei Mengqi#, Wen Didi, Zhao Hongliang, Liu Ying, Li Jiayi, Li Jian. Transluminal attenuation gradient in coronary computed tomography angiography for determining stenosis severity of calcified coronary artery: a primary study with dual-source CT. Eur Radiol. 2015 May, 25(5):1219-1228.

（33）Wei Mengqi#, Wen Didi#, Wang Xiaoying, Huan Yi, Xu Jian, Cheng Kang*, Zheng Minwen*. Experimental study of endothelial progenitor cells labeled with superparamagnetic iron oxide in vitro. Mol Med Rep. 2015 May, 11(5):3814-3819.

（34）Zheng Minwen, Wu Yongjie, Wei Mengqi, Liu Ying, Zhao Hongliang, Li Jian. Low-concentration contrast medium for 128-slice dual-source CT coronary angiography at a very low radiation dose using prospectively ECG-triggered high-pitch spiral acquisition. Acad Radiology. 2015 Feb, 22(2):195-202.

（35）Xu Jian, Zhao Hongliang, Wang Xiaoying, Bai Yuxiang, Liu Liwen, Liu Ying, Wei Mengqi, Li Jian, Zheng Minwen*. Accuracy, image quality and radiation dose of prospectively ECG-triggered high-pitch dual-source CT angiography in infants and children with complex coarctation of the aorta. Acad Radiology. 2014 Oct, 21(10):1248-1254.

（36）Zheng Minwen, Liu Ying, Wei Mengqi, Wu Yongjie, Zhao Hongliang, Li Jian. Low concentration contrasts medium or dual-source computed tomography coronary angiography by a combination of iterative reconstruction and low-tube-voltage technique: Feasibilitystudy. Eur J Radiol. 2014 Feb, 83(2): e92-9.（IF=2.512）

（37）Liu Ying#, Xu Jian#, Li Jian, Ren Jing, Liu Hongtao, Xu Junqing, Wei Mengqi, Hao Yuewen, Zheng Minwen*. The ascending aortic image quality and the whole aortic radiation dose of high-pitch dual-source CT angiography. Journal of Cardiothoracic Surgery. 2013 Dec, 8:228-232.

（38）Zheng Minwen*, Zhao Hongliang, Xu Jian, Wu Yongjie, Li Jian. Image quality of ultra-low dose dual-source CT angiography using high-pitch spiral acquisition and iterative reconstruction in young children with congenital heart disease. J Cardiovasc Comput Tomogr. 2013 Nov-Dec, 7(6):376-382

（39）Liu Ying, Ren Jing, Li Jian, Zheng Minwen*. Renal artery to inferior vena cava fistula after nephrectomy. J Vasc Surg. 2013 Oct, 1 (4): 417.

（40）Li Jiayi, Li Xue, Wei Mengqi, Zhao Hongliang, Zheng Minwen*. Diagnostic accuracy of dual-source computed tomography in the detection of coronary chronic total occlusion: comparison with invasive angiography. African Journal of Biotechnology, 2011 May, 10(19): 3854-3858.

（41）Li Jiayi, Wang Haichang, Zheng Minwen*. Diagnosis of aortic-right ventricular tunnel by dual-source computed tomography. European Journal of Cardio-thoracic Surgery. 2011 Apr,39(4):609.

（42）Gong Li#, Zheng Minwen#, Li Y, Zhang W, Bu W, Shi L, Zhang W, Yan H. Seminal vesicle metastasis after partial hepatectomy for hepatocellular carcinoma. BMC Cancer. 2011 Mar, 11:111.

（43）Li Jiayi, Zheng Minwen*. Aortic Arch Interruption with Thoracic Aortic Dissection. The Annals of Thoracic Surgery. 2011 Feb, 91(2): 615.

（44）Zheng Minwen*, Li Jiayi, Xu Jian, Huan Yi. Spontaneous Dissection of Left Anterior Descending Coronary Artery: the diagnostic role of dual-source computed tomography. Journal of Thoracic Imaging. 2010 Aug, 25(3):W79-W81.

（45）Zheng Minwen, Li J, Xu J, Chen K, Zhao H, Huan Y. Dual-source computed tomography coronary angiography: image quality in patients with high heart rates. Tex Heart Inst J. 2009, 36(2):117-124.

著作教材：

（1）《中华影像鉴别诊断学-心血管分册》，人民卫生出版社，2024，主编

（2）《中国医学影像人工智能》英文版. 人民卫生出版社. 2024，参编

（3）《现代体部磁共振诊断学-胸部分册》，复旦大学出版社，2023，主编

（4）全国高等学校医学影像学专业第五轮规划教材《医学影像学导论》，人民卫生出版社，2022，编委

（5）《医学影像成像》，人民卫生出版社，2022，主编

（6）“十三五”国家重点图书出版规划项目，“一带一路”背景下国际化临床医学丛书《医学影像学》英文版，郑州大学出版社，2020，副主编

（7）《X线/CT医学影像诊断学》，科学出版社，2022，编委

（8）国家卫生和计划生育委员会“十三五”规划教材-临床型研究生及专科医师《心血管放射诊断学》，人民卫生出版社，2018，参编

（9）国家卫生和计划生育委员会“十三五”规划教材-临床型研究生及专科医师《胸部放射诊断学》，人民卫生出版社，2018，参编

（10）《肺血管病及精选病例解析》，人民卫生出版社，2017，副主编

（11）《中华医学影像案例解析宝典-心胸分册》，人民卫生出版社，2017，参编

授权专利：

(1) ×××，一种治疗糖耐量异常的药物组合物及其制备方法，2010 年 6 月 2 日，中国，ZL2007101060118；

(2) ×××，×××，一种治疗糖调节受损的药物组合物及其制备方法，2017 年11 月 10 日，中国，ZL201310201329.X。

（1）郑敏文，殷亚亚，李剑. 一种鼻窦冠状位CT扫描支撑架. 2016年10月26日，中国，ZL201620194979.5。

（2）郑敏文，李剑，殷亚亚. 一种乳腺检查用支架. 2016年06月08日，中国，ZL201521049434.7。

（3）郑敏文，宦怡，殷亚亚. 一种女性病人胸部CT穿刺皮肤固定装置. 2015年12月30日，中国，ZL201520499327.8。

（4）郑敏文，张劲松. 一种CT成像时的下肢固定装置. 2015年11月18日，中国， ZL201520362756.0。

（5）郑敏文，殷亚亚. 一种心脏双源CT检查专用辅助闭气装置. 2015年11月11日，中国，ZL201520389398.2。

（6）张劲松，郑敏文，殷亚亚. 一种CT专用手臂固定架. 2015年08月12日，中国，ZL201520213048.0。

（7）郑敏文，徐建. 一种溶栓导管固定装置. 2015年07月29日，中国，ZL201520145108.X。

（8）宦怡，魏梦绮，袁远，郑敏文，张劲松，杨勇，任静，黄旭方，赵亚超，李昕宇. 一种用于前列腺癌早期诊断和治疗的抗PSMA/FITC双特异抗体及其制备方法. 2015年01月14日， 中国ZL201210564978.1。

获奖情况：

（1）郑敏文，任静，尉胜男，徐健，黄亚渝，彭锐，郭钒，文娣娣，安睿（1/9），军队基层放射影像“三岗合一、三能胜任”教学体系的构建与实践，中央军委训练管理部，军队教学成果奖，一等奖，2024年

（2）郑敏文，宦怡，孙立军，李家一，刘莹，葛雅丽，魏梦琦，徐健，石明国（1/9），CT/MR新技术在心血管疾病诊断和治疗中的应用研究，陕西省人民政府，陕西省科学技术奖，二等奖，2012年

（3）郑敏文，孙立军，宦怡，葛雅丽，江菊芬，韩月东，刘莹，郭苏晋，李敬邦（1/9），磁共振与电子束CT对心血管疾病的临床综合诊断价值评估，陕西省人民政府，陕西省科学技术奖，二等奖，2006年

（4）郑敏文，尉胜男，彭锐，任静，张劲松，徐健，魏梦绮，刘莹，郭钒（1/9），基于胜任能力的基层影像医师执业教育MOOC平台构建，空军军医大学，教学成果奖，二等奖，2019年

（5）印弘，张艰，郑敏文，张劲松，宦怡，袁怀平，刘莹（3/7）, 影像医学计算机互动式教学平台及题库的建立，陕西省人民政府，陕西省教学成果奖，一等奖，2015年

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