个人简介：

张小玲，女，1974年8月22日出生，研究生学历，博士学位，主任医师/教授职称，陕西中医药大学硕士研究生指导教师。现任陕西省人民医院医务处处长，兼任中华医学会放射学分会青年委员，陕西省研究型医院学会肿瘤影像诊断学专业委员会主任委员，陕西省抗癌协会肿瘤影像专业委员会常委及青年委员会副主任委员，中国研究型医院学会肿瘤影像诊断专业委员会委员，陕西省老年保健医学会第二届理事会理事，陕西省医师协会放射科医师分会副会长，陕西省医师协会放射医师分会副主任委员，陕西省保健协会影像专业委员会副主任委员，全国放射影像学名词编写委员会委员，陕西省医疗器械临床使用专家委员会委员，中国研究型医学学会磁共振专业委员会委员，中国医学装备协会磁共振应用专业委员会委员，陕西省保健学会影像专业委员会副主任委员，中国卒中学会医学影像分会第二届委员会委员，陕西省医学会放射学分会常务委员等。

学习工作经历：

1996年7月本科毕业于西安医科大学，硕士毕业于西安交通大学，博士毕业于西安交通大学，在陕西省人民医院工作，主要从事影像医学诊断工作29年。

研究方向：

神经及精神疾病影像学研究； 磁共振功能成像临床应用研究

科研课题：

（1）国家自然科学基金面上项目，脑网络和代谢网络交互在人血糖中枢调控中的作用研究，2022-01至2025-12，在研，55万元，主持；

（2）陕西省卫生健康人才培训行动-人才创新团队，糖尿病代谢紊乱机制影像组学研究科研创新团队，2024-06至2025-06，在研，25万元，主持。

（3）陕西省重点研发计划重点项目（社会发展领域），基模态磁共振成像对糖尿病相关认知功能障碍的纵向量化评价研究，2023-06至2027-06，在研，50万元，主持。

（4）陕西省人民医院领军人才项目，脑网络和代谢网络交互在人血糖中枢调控中的作用研究，2022-05至2026-05，在研，80万，主持。

发表论文：

1. Huang Y, Zhang X, Cheng M, Yang Z, Liu W, Ai K, Tang M, Zhang X, Lei X, Zhang D. Altered cortical thickness-based structural covariance networks in type 2 diabetes mellitus. Front Neurosci. 2024 Jan 24;18:1327061.  

2. Zhang D, Huang Y, Liu S, Gao J, Liu W, Liu W, Ai K, Lei X, Zhang X. Structural and functional connectivity alteration patterns of the cingulate gyrus in Type 2 diabetes. Ann Clin Transl Neurol. 2023;10(12):2305-2315.（通讯作者,IF=5.300, Q2）

3. Zhang D, Liu S, Huang Y, Gao J, Liu W, Liu W, Ai K, Lei X, Zhang X. Altered Functional Connectivity Density in Type 2 Diabetes Mellitus with and without Mild Cognitive Impairment. Brain Sci. 2023 Jan 13;13(1):144. 

4. Yan X, Tang M, Gao J, Wang L, Li L, Ma N, Shi X, Lei X, Zhang X. Sex Differences in Intracranial Atherosclerotic Plaques Among Patients With Ischemic Stroke. Front Cardiovasc Med. 2022 Jun 30;9:860675. 

5. Wang M, Zhang D, Gao J, Qi F, Su Y, Lei Y, Shao Z, Ai K, Tang M, Zhang X. Abnormal functional connectivity in the right dorsal anterior insula associated with cognitive dysfunction in patients with type 2 diabetes mellitus. Brain Behav. 2022 May 11:e2553.  

6. Tang M, Yan X, Gao J, Li L, Zhe X, Zhang X, Jiang F, Hu J, Ma N, Ai K, Zhang X. High-Resolution MRI for Evaluation of the Possibility of Successful Recanalization in Symptomatic Chronic ICA Occlusion: A Retrospective Study. AJNR Am J Neuroradiol. 2022 Aug;43(8):1164-1171.

7. Tang M, Gao J, Ma N, Yan X, Zhang X, Hu J, Zhuo Z, Shi X, Li L, Lei X, Zhang X. Radiomics Nomogram for Predicting Stroke Recurrence in Symptomatic Intracranial Atherosclerotic Stenosis. Front Neurosci. 2022 Apr 12;16:851353. 

8. Tang M, Gao J, Gao J, Yan X, Zhang X, Li L, Xia Z, Lei X, Zhang X. Evaluating intracranial artery dissection by using three-dimensional simultaneous non-contrast angiography and intra-plaque hemorrhage high-resolution magnetic resonance imaging: a retrospective study. Acta Radiol. 2022 Mar;63(3):401-409.

9. Li L, Tang M, Yan X, Gao J, Ma N, Shi X, Niu Y, Wen Y, Ai K, Lei X, Zhang X. Plaque Characteristics in Young Adults With Symptomatic Intracranial Atherosclerotic Stenosis: A Preliminary Study. Front Neurol. 2022 Feb 10;13:825503.

10. Huang Y, Zhang D, Zhang X, Cheng M, Yang Z, Gao J, Tang M, Ai K, Lei X, Zhang X. Altered functional hubs and connectivity in type 2 diabetes mellitus with and without mild cognitive impairment. Front Neurol. 2022 Dec 12;13:1062816.

11. Lei Y, Zhang D, Qi F, Gao J, Tang M, Ai K, Yan X, Lei X, Shao Z, Su Y, Zhang X. Dysfunctional Interaction Between the Dorsal Attention Network and the Default Mode Network in Patients With Type 2 Diabetes Mellitus. Front Hum Neurosci. 2021 Dec 24;15:796386.

12. Zhang D, Huang Y, Gao J, Lei Y, Ai K, Tang M, Yan X, Lei X, Yang Z, Shao Z, Zhang X. Altered Functional Topological Organization in Type-2 Diabetes Mellitus With and Without Microvascular Complications. Front Neurosci. 2021 Sep 22;15:726350. doi: 10.3389/fnins.2021.726350. eCollection 2021.

13. Yan X, Gao J, Tang M, Zhang D, Li L, Wang L, Lei X, Zhang X. Combined Assessment of Elevated Plasma Lipoprotein-Associated Phospholipase A₂ and Plaque Enhancement Improved Accuracy in the Risk of Acute Ischemic Stroke in Patients with Intracranial Artery Stenosis. J Stroke Cerebrovasc Dis. 2021Dec;30(12):106103.

14. Zhe X, Chen L, Zhang D, Tang M, Gao J, Ai K, Liu W, Lei X, Zhang X. Cortical Areas Associated With Multisensory Integration Showing Altered Morphology and Functional Connectivity in Relation to Reduced Life Quality in Vestibular Migraine. Front Hum Neurosci. 2021 Aug 16;15:717130.

15. Zhang D, Wang M, Gao J, Huang Y, Qi F, Lei Y, Ai K, Yan X, Cheng M, Su Y, Lei X, Zhang X. Altered Functional Connectivity of Insular Subregions in Type 2 Diabetes Mellitus. Front Neurosci. 2021 Jun 16;15:676624.

16. Zhang D, Lei Y, Gao J, Qi F, Yan X, Ai K, Zhe X, Cheng M, Wang M, Su Y, Tang M, Zhang X. Right Frontoinsular Cortex: A Potential Imaging Biomarker to Evaluate T2DM-Induced Cognitive Impairment. Front Aging Neurosci. 2021 May 28;13:674288.

17. Qi F, Zhang D, Gao J, Tang M, Wang M, Su Y, Lei Y, Shao Z, Zhang X. Functional Disconnection of the Angular Gyrus Related to Cognitive Impairment in Patients With Type 2 Diabetes Mellitus. Front Hum Neurosci. 2021 Feb 3;15:621080.

18. Tang M, Gao J, Gao J, Yan X, Zhang X, Li L, Xia Z, Lei X, Zhang X. Evaluating intracranial artery dissection by using three-dimensional simultaneous non-contrast angiography and intra-plaque hemorrhage high-resolution magnetic resonance imaging: a retrospective study. Acta Radiol. 2022 Mar;63(3):401-409.

19. Zhang D, Qi F, Gao J, Yan X, Wang Y, Tang M, Zhe X, Cheng M, Wang M, Xie Q, Su Y, Zhang X. Altered Cerebellar-Cerebral Circuits in Patients With Type 2 Diabetes Mellitus. Front Neurosci. 2020 Sep 24;14:571210.

20. Gao J, Zhang D, Wang L, Wang W, Fan Y, Tang M, Zhang X, Lei X, Wang Y, Yang J, Zhang X. Altered Effective Connectivity in Schizophrenic Patients With Auditory Verbal Hallucinations: A Resting-State fMRI Study With Granger Causality Analysis. Front Psychiatry. 2020 Jun 24;11:575.

21. Zhang D, Gao J, Yan X, Tang M, Zhe X, Cheng M, Chen W, Zhang X. Altered functional connectivity of brain regions based on a meta-analysis in patients with T2DM: A resting-state fMRI study. Brain Behav. 2020 Aug;10(8):e01725.

22. Zhe X, Gao J, Chen L, Zhang D, Tang M, Yan X, Bai F, Zhang X, Zou Z, Chen W, Lei X, Zhang X. Altered structure of the vestibular cortex in patients with vestibular migraine. Brain Behav. 2020 Apr;10(4):e01572.

著作教材：

(1)《脑疾病与影像新技术》，研究生“十四五”规划精品系列教材，西安交通大学,2024，编委。

授权专利：

(1)张小玲，一种基于迁移学习的医学图像分割与显示方法，2020年11月23，中国，ZL202011324115.8。

获奖情况：

（1）张小玲（1/6），MRI新技术在中枢神经系统疾病的临床推广应用，陕西省科技进步奖，三等奖，2020年。

联系方式：zxl.822@163.com